VIRTUheart Publications

Wearable technology and the cardiovascular system: the future of patient assessment. Williams GJ, Al-Baraikan A, Rademakers FE, Ciravegna F, van de Vosse FN, Lawrie A, Rothman A, Ashley EA, Wilkins MR, Lawford PV, Omholt SW, Wisløff U, Hose DR, Chico TJA, Gunn JP, Morris PD. 

Lancet Digit Health. 2023 Jul;5(7):e467-e476. doi 10.1016/S2589-7500(23)00087-0. PMID: 37391266

Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model. Taylor DJ, Aubiniere-Robb L, Gosling R, Newman T, Hose DR, Halliday I, Lawford PV, Narracott AJ, Gunn JP and Morris PD. 2023. 

Front. Cardiovasc. Med. https://doi.org/10.3389/fcvm.2023.1159160 

Rapid virtual fractional flow reserve using 3D computational fluid dynamics. Newman T,  Borker R,  Aubiniere-Robb L,  Hendrickson J, Choudhury D, Halliday I, Fenner J, Narracott A, Hose DR, Gosling R, Gunn JP, Morris PD. 

Eur Heart J Digit Health. 2023. 00, 1–8. https://doi.org/10.1093/ehjdh/ztad028

Modelling The Hemodynamics of Coronary Ischemia. Al Baraikan A, Czechowicz K, Morris PD, Halliday I. Gosling RC, Gunn JP, Narracott AJ, Williams G, Garg P, Malawski M, Frans van de Vosse, Lungu A, Rafiroiu D, D. Rod Hose. 

Fluids. 2023, 8, 159. doi: 10.3390/fluids8050159

Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries. Taylor DJ, Feher J, Czechowicz K, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, Van't Veer M, Keulards DCJ, Tonino P, Rochette M, Gunn JP, Morris PD.
Eur Heart J Digit Health. 2023 Jan 3;4(2):81-89. doi: 10.1093/ehjdh/ztac077. eCollection 2023 Mar.
PMID: 36974271

Quantifying Myocardial Blood Flow and Resistance Using 4D-Flow Cardiac Magnetic Resonance Imaging. Gosling RC, Williams G, Al Baraikan A, Alabed S, Levelt E, Chowdhary A, Swoboda PP, Halliday I, Hose DR, Gunn JP, Greenwood JP, Plein S, Swift AJ, Wild JM, Garg P, Morris PD.
Cardiol Res Pract. 2023 Feb 2;2023:3875924. doi: 10.1155/2023/3875924. eCollection 2023.
PMID: 36776959 Free PMC article.

Validation of time-resolved, automated peak trans-mitral velocity tracking: Two center four-dimensional flow cardiovascular magnetic resonance study.
Njoku P, Grafton-Clarke C, Assadi H, Gosling R, Archer G, Swift AJ, Morris PD, Albaraikan A, Williams G, Westenberg J, Aben JP, Ledoux L, Alabed S, Flather M, Cameron D, Cabrero JB, Val JRD, Nair S, Ryding A, Sawh C, Swoboda PP, Levelt E, Chowdhary A, Vassiliou V, Zhong L, Garg P.
Int J Cardiol. 2022 Oct 1;364:148-156. doi: 10.1016/j.ijcard.2022.06.032. Epub 2022 Jun 16.
PMID: 35716937

Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve.
Gosling RC, Gunn E, Wei HL, Gu Y, Rammohan V, Hughes T, Hose DR, Lawford PV, Gunn JP, Morris PD.
Eur Heart J Digit Health. 2022 Sep 5;3(3):481-488. doi: 10.1093/ehjdh/ztac045. eCollection 2022 Sep.
PMID: 36712154 Free PMC article.

Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents.
Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G, Chiastra C, Halliday I, Morris PD, Evans PC, C M P.
PLoS One. 2022 Jul 28;17(7):e0271469. doi: 10.1371/journal.pone.0271469. eCollection 2022.
PMID: 35901129 Free PMC article.

The Complementary Value of Absolute Coronary Flow in the Assessment of Patients with Ischaemic Heart Disease (the COMPAC-Flow Study).
Aubiniere-Robb L, Gosling R, Taylor DJ, Newman T, Rodney D, Ian Halliday H, Lawford PV, Narracott AJ, Gunn JP, Morris PD.
Nat Cardiovasc Res. 2022 Jul;1(7):611-616. doi: 10.1038/s44161-022-00091-z. Epub 2022 Jul 4.
PMID: 35865080 Free PMC article.

Refining Our Understanding of the Flow Through Coronary Artery Branches; Revisiting Murray's Law in Human Epicardial Coronary Arteries.
Taylor DJ, Feher J, Halliday I, Hose DR, Gosling R, Aubiniere-Robb L, van 't Veer M, Keulards D, Tonino PAL, Rochette M, Gunn J, Morris PD.
Front Physiol. 2022 Apr 4;13:871912. doi: 10.3389/fphys.2022.871912. eCollection 2022.
PMID: 35600296 Free PMC article.

Virtual (Computed) Fractional Flow Reserve: Future Role in Acute Coronary Syndromes.
Haley HA, Ghobrial M, Morris PD, Gosling R, Williams G, Mills MT, Newman T, Rammohan V, Pederzani G, Lawford PV, Hose R, Gunn JP.
Front Cardiovasc Med. 2021 Oct 22;8:735008. doi: 10.3389/fcvm.2021.735008. eCollection 2021.
PMID: 34746253 Free PMC article. Review.

The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.
Solanki R, Gosling R, Rammohan V, Pederzani G, Garg P, Heppenstall J, Hose DR, Lawford PV, Narracott AJ, Fenner J, Gunn JP, Morris PD.
Sci Rep. 2021 Oct 4;11(1):19694. doi: 10.1038/s41598-021-99065-7.
PMID: 34608218 Free PMC article.

The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study.
Newcombe RTF, Gosling RC, Rammohan V, Lawford PV, Hose DR, Gunn JP, Morris PD.
Eur Heart J Digit Health. 2021 Aug 15;2(4):616-625. doi: 10.1093/ehjdh/ztab075. eCollection 2021 Dec.
PMID: 35599684 Free PMC article.

Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment.
Lal K, Gosling R, Ghobrial M, Williams GJ, Rammohan V, Hose DR, Lawford PV, Narracott A, Fenner J, Gunn JP, Morris PD.
Eur Heart J Digit Health. 2021 Feb 5;2(2):263-270. doi: 10.1093/ehjdh/ztab012. eCollection 2021 Jun.
PMID: 34223175 Free PMC article.

The Impact of Virtual Fractional Flow Reserve and Virtual Coronary Intervention on Treatment Decisions in the Cardiac Catheter Laboratory.
Gosling RC, Adam Z, Barmby DS, Iqbal J, Morgan KP, Richardson JD, Rothman AMK, Lawford PV, Hose DR, Gunn JP, Morris PD.
Can J Cardiol. 2021 Oct;37(10):1530-1538. doi: 10.1016/j.cjca.2021.06.004. Epub 2021 Jun 12.
PMID: 34126226 Free PMC article.

Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.
Mills MT, Grafton-Clarke C, Williams G, Gosling RC, Al Baraikan A, Kyriacou AL, Morris PD, Gunn JP, Swoboda PP, Levelt E, Tsampasian V, van der Geest RJ, Swift AJ, Greenwood JP, Plein S, Vassiliou V, Garg P.
Wellcome Open Res. 2021 May 18;6:73. doi: 10.12688/wellcomeopenres.16655.2. eCollection 2021.
PMID: 34095509 Free PMC article.

The new role of diagnostic angiography in coronary physiological assessment.
Ghobrial M, Haley HA, Gosling R, Rammohan V, Lawford PV, Hose DR, Gunn JP, Morris PD.
Heart. 2021 May;107(10):783-789. doi: 10.1136/heartjnl-2020-318289. Epub 2021 Jan 8.
PMID: 33419878 Free PMC article. Review.

A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease.
Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR, Lawford PV, Narracott AJ, Gunn JP.
Cardiovasc Res. 2021 May 25;117(6):1567-1577. doi: 10.1093/cvr/cvaa220.
PMID: 32666101 Free PMC article.

Angiography-Derived Fractional Flow Reserve: More or Less Physiology?
Morris PD, Curzen N, Gunn JP.
J Am Heart Assoc. 2020 Mar 17;9(6):e015586. doi: 10.1161/JAHA.119.015586. Epub 2020 Mar 11.
PMID: 32157954 Free PMC article. No abstract available.

Effect of side branch flow upon physiological indices in coronary artery disease.
Gosling RC, Sturdy J, Morris PD, Fossan FE, Hellevik LR, Lawford P, Hose DR, Gunn J.
J Biomech. 2020 Apr 16;103:109698. doi: 10.1016/j.jbiomech.2020.109698. Epub 2020 Feb 26.
PMID: 32151377

Double-Kissing Nanocrush for Bifurcation Lesions: Development, Bioengineering, Fluid Dynamics, and Initial Clinical Testing.
Morris PD, Gosling R, Rothman A, Iqbal J, Chiastra C, Colombo M, Migliavacca F, Banning A, Gunn JP.
Can J Cardiol. 2020 Jun;36(6):852-859. doi: 10.1016/j.cjca.2019.08.037. Epub 2019 Aug 30.
PMID: 32088059 Free PMC article.

Personalised fractional flow reserve: a novel concept to optimise myocardial revascularisation.
Gosling RC, Morris PD, Lawford PV, Hose DR, Gunn JP.
EuroIntervention. 2019 Oct 20;15(8):707-713. doi: 10.4244/EIJ-D-18-00668.
PMID: 30561366

Non-invasive Stenotic Renal Artery Haemodynamics by in silico Medicine
Mandaltsi A, Grytsan A, Odudu A, Kadziela J, Morris PD, Witkowski A, Ellam T, Kalra P, Marzo A.
Front Physiol. 2018 Aug 17;9:1106. doi: 10.3389/fphys.2018.01106. eCollection 2018.
PMID: 30174610 Free PMC article.

Predictive Physiological Modeling of Percutaneous Coronary Intervention - Is Virtual Treatment Planning the Future?
Gosling RC, Morris PD, Lawford PV, Hose DR, Gunn JP.
Front Physiol. 2018 Aug 13;9:1107. doi: 10.3389/fphys.2018.01107. eCollection 2018.
PMID: 30154734 Free PMC article. Review.

Simultaneous kissing stents to treat unprotected left main stem coronary artery bifurcation disease; stent expansion, vessel injury, hemodynamics, tissue healing, restenosis, and repeat revascularization.
Morris PD, Iqbal J, Chiastra C, Wu W, Migliavacca F, Gunn JP.
Catheter Cardiovasc Interv. 2018 Nov 15;92(6):E381-E392. doi: 10.1002/ccd.27640. Epub 2018 Apr 25.
PMID: 29693768 Free PMC article.

Virtual Coronary Intervention: A Treatment Planning Tool Based Upon the Angiogram.
Gosling RC, Morris PD, Silva Soto DA, Lawford PV, Hose DR, Gunn JP.
JACC Cardiovasc Imaging. 2019 May;12(5):865-872. doi: 10.1016/j.jcmg.2018.01.019. Epub 2018 Mar 14.
PMID: 29550308 Free PMC article.

The impact of Objective Mathematical Analysis during Fractional Flow Reserve measurement: results from the OMA-FFR study
Sciola MI, Morris PD, Gosling R, Lawford PV, Hose DR, Gunn JP.
EuroIntervention. 2018 Oct 20;14(8):935-941. doi: 10.4244/EIJ-D-17-00826.
PMID: 29437033

Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study
Morris PD, Silva Soto DA, Feher JFA, Rafiroiu D, Lungu A, Varma S, Lawford PV, Hose DR, Gunn JP.
JACC Basic Transl Sci. 2017 Aug 28;2(4):434-446. doi: 10.1016/j.jacbts.2017.04.003. eCollection 2017 Aug.
PMID: 28920099 Free PMC article.

Computational fluid dynamics modelling in cardiovascular medicine.
Morris PD, Narracott A, von Tengg-Kobligk H, Silva Soto DA, Hsiao S, Lungu A, Evans P, Bressloff NW, Lawford PV, Hose DR, Gunn JP.
Heart. 2016 Jan;102(1):18-28. doi: 10.1136/heartjnl-2015-308044. Epub 2015 Oct 28.
PMID: 26512019 Free PMC article. Review.

When is rotational angiography superior to conventional single-plane angiography for planning coronary angioplasty?
Morris PD, Taylor J, Boutong S, Brett S, Louis A, Heppenstall J, Morton AC, Gunn JP.Catheter Cardiovasc Interv. 2016 Mar;87(4):E104-12. doi: 10.1002/ccd.26032. Epub 2015 May 27. PMID: 26012725 Free PMC article.

"Virtual" (Computed) Fractional Flow Reserve: Current Challenges and Limitations.
Morris PD, van de Vosse FN, Lawford PV, Hose DR, Gunn JP.
JACC Cardiovasc Interv. 2015 Jul;8(8):1009-1017. doi: 10.1016/j.jcin.2015.04.006. Epub 2015 Jun 24.
PMID: 26117471 Free PMC article. Review.

Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Çimen S, Hoogendoorn C, Morris PD, Gunn J, Frangi AF.
Med Image Comput Comput Assist Interv. 2014;17(Pt 2):619-26. doi: 10.1007/978-3-319-10470-6_77.PMID: 25485431

Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.
Morris PD, Ryan D, Morton AC, Lycett R, Lawford PV, Hose DR, Gunn JP.
JACC Cardiovasc Interv. 2013 Feb;6(2):149-57. doi: 10.1016/j.jcin.2012.08.024.
PMID: 23428006